Books and key references

Research context for monitoring, including the first PANS/PANDAS offering.

These references support educational framing only. RubyHealth summaries are not diagnostic claims and must be reviewed with qualified clinicians.

Head and brain educational infographic for RubyHealth key references

Why these references matter.

RubyHealth's content strategy connects several evidence areas: PANS/PANDAS assessment, autism as a distinct neurodevelopmental condition, symptom measurement, wearable limitations, and sleep or autonomic context.

The product goal is to help organise context for review, not to replace physician judgement.

How RubyHealth uses this research.

The content framework keeps diagnosis separate from observation. Published clinical guidance informs the symptom fields; wearable research informs contextual trends and their limitations.

The app should help families and clinicians see patterns over time: what changed, when it changed, and which signals moved together.

Reference list

Core papers to cite in future content.

American Academy of Pediatrics (2025)Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Clinical Report.Open AAP clinical report

National Institute of Mental HealthPANS and PANDAS: Questions and Answers.Open NIMH overview

World Health Organization (2025)Autism fact sheet: definition, characteristics, support, and evidence context.Open WHO fact sheet

NICE guideline CG170Autism spectrum disorder in under 19s: support and management.Open NICE guidance

PANS 31-Item Symptom Rating Scale (2024)Development and validation research informing consistent symptom-domain observation.Open PubMed record

PANS and neurodevelopmental disorders study (2026)Recent observational evidence on neurodevelopmental comorbidity in a PANS clinical sample; association does not establish causation.Open European Journal of Paediatric Neurology article

Pediatric wearable review (2022)Wearable sensors for pediatric health monitoring, including validation and implementation limitations.Open review

Tracey, K.J. (2002)The inflammatory reflex. Nature, 420, 853-859.Open Nature article

Mishra, T. et al. (2020)Pre-symptomatic detection of COVID-19 from smartwatch data. Nature Biomedical Engineering, 4, 1208-1220.Open Nature article

Thayer, J.F. et al. (2010)Autonomic imbalance, HRV and cardiovascular disease risk factors. International Journal of Cardiology, 141(2), 122-131.Open DOI

Irwin, M.R. & Opp, M.R. (2017)Sleep health: reciprocal regulation of sleep and innate immunity. Neuropsychopharmacology, 42(1), 129-155.Open PubMed

Swedo, S.E. et al. (2012)Modifying the PANDAS criteria to describe PANS. Pediatrics & Therapeutics, 2(2).Open article

Chang, K. et al. (2015)Clinical evaluation of youth with PANS. Journal of Child and Adolescent Psychopharmacology, 25(1), 3-13.Open article

Krueger, J.M. et al. (2008)Sleep as a fundamental property of neuronal assemblies. Nature Reviews Neuroscience, 9, 910-919.Open Nature article

Besedovsky, L. et al. (2019)The sleep-immune crosstalk in health and disease. Physiological Reviews, 99(3), 1325-1380.Open DOI

Dantzer, R. et al. (2008)From inflammation to sickness and depression. Nature Reviews Neuroscience, 9(1), 46-56.Open Nature article